Endocrine Abstracts

Hashimoto’s thyroiditis (HT) is usually characterized by goiter and/or hypothyroidism. Thyroid pain and tenderness are rare and suggest an alternative diagnostic of subacute thyroiditis (SAT).We present two cases of painful HT, who had temporary relief with corticosteroids and required surgical intervention for persistent pain. Both patients were middle-aged women with painful goiter, fever, and inflammatory syndrome. Thyroid function was normal, an...

Introduction: Primary adrenal insufficiency (PAI) is a potentially life – threatening condition. About 75–80% of cases of PAI are caused by autoimmune destruction, while TB accounts for 7–20% of cases; however, adrenal tuberculosis is still the primary cause of PAI in developing countries. Adrenal tuberculosis is difficult to diagnose because symptoms are non-specific. Moreover, if the patient had no prior contact with TB patients, no past history of pulmonary T...

Introduction: Although concomitant primary hyperparathyroidism (PHPT) and papillary thyroid carcinoma (PTC) has been repeatedly reported in medical literature with an incidence of 2.3–4.3%, no causal relationship has been elucidated. In most cases, diagnosis of PTC is mostly incidentally, while PHPT is usually the primary pathology. Recent literature supports the possible role of dual-phase 99mTc-MIBI parathyroid imaging in detecting PTC in patients with PHPT.<...

Introduction: Plurihormonal pituitary adenomas are unusual tumors which typically belong to one cell lineage and have an incidence of approximately 1.3%, the most common combination being GH, PRL and glycoprotein hormone subunits. There are a few cases in the literature describing cosecretion of GH and ACTH from a pituitary adenoma, the incriminated pathogenesis being the origin from different cell lineages and the aberrant patterns of transcription factors.<p class="abste...

Introduction: Central hyperthermia is frequent in patients with brain injury and is characterized by a rapid onset with high temperatures, marked temperature fluctuations and poor response to antipyretics. It is associated with worse outcomes in the injured brain, thus it is important to aggressively manage it.Case-report: We report a case of a 9-year-old boy diagnosed with sellar and suprasellar adamantimomatous craniopharyngioma at the age of 5 when he...

Introduction: Inappropriate secretion of TSH, despite elevated levels of T4, is due to either a TSH-secreting adenoma (TSHoma) or thyroid hormone resistance (RTH). RTH is a rare disorder, usually caused by mutations in the thyroid hormone receptor beta, characterized by a variable tissue hyporesponsiveness to thyroid hormone. The increased level of TSH may predispose to thyrotroph hyperplasia and possible adenoma formation.Case report: A 21 years old fem...

Introduction: Synchronous medullary thyroid cancer and pHPT is common in MEN-2A (Sipple syndrome). In contrast, concomitant nonmedullary thyroid cancer and primary hyperparathyroidism (PHPT) is very rare even if the pathological relationship between parathyroid and thyroid diseases is common.Aim: Was to determine the prevalence of non-medullary thyroid carcinoma in patient who underwent neck exploration for PHPT.Patients and method...

IntroductionBody composition (BC), adipokines and the fibroblast growth factor-23 (FGF23) - Klotho axis interfere with bone metabolism and also suffer important modifications in acromegaly. We aimed to investigate their influence upon bone in active acromegaly, compared to controls.MethodsWe performed a cross sectional study, investigating the adipokines (leptin, adiponectin, resistin) secretion pattern, BC p...

IntroductionMayer-Rokitansky-Küster-Hauser (MRKH) type 2 or MURCS (Müllerian duct aplasia, unilateral renal agenesis and cervicothoracic somite anomalies) syndrome is a congenital disease with an incidence of 1 in 4000–5000 female live births, with unknown etiology. Several chromosomal abnormalities were associated with the disease, with a normal 46XX karyotype and familial members to share the same associated anomalies as sporadic cases h...

Introduction: Prolactinomas, prevalent among young women, are the most frequently encountered secreting pituitary tumors. Pituitary apoplexy is a rare and severe complication of prolactinomas, which manifests with rapid onset symptoms like severe headaches, visual disturbances, hormonal imbalances, requiring urgent medical care.Case report: We report the case of a 46-year-old female patient with history of type 2 diabetes, early menopause (30 years old, ...